Publications
Evidence that the cold- and menthol-sensing functions of the human TRPM8 channel evolved separately
Sci Adv. (2024) Jun 21;10(25):eadmn9228. doi: 10.1126/sciadv.adm9228. Epub 2024 Jun 21. PubMed PMID: 38905339; PubMed Central PMCID: PMC 11192081
Luu DD, Ramesh N, Kazan IC, Shah KH, Lahiri G, Mana MD, Ozkan SB, Van Horn WD.
Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival
bioRxiv. (2023) Dec 1;. doi: 10.1101/2023.11.30.569407. PubMed PMID: 38077056; PubMed Central PMCID: PMC10705501
Tzouanas CN, Sherman MS, Shay JES, Rubin AJ, Mead BE, Dao TT, Butzlaff T, Mana MD, Kolb KE, Walesky C, Pepe-Mooney BJ, Smith CJ, Prakadan SM, Ramseier ML, Tong EY, Joung J, Chi F, McMahon-Skates T, Winston CL, Jeong WJ, Aney KJ, Chen E, Nissim S, Zhang F, Deshpande V, Lauer GM, Yilmaz ÖH, Goessling W, Shalek AK.
Stiffness Restricts the Stemness of the Intestinal Stem Cells and Skews Their Differentiation Toward Goblet Cells
Gastroenterology. (2023) Jun;164(7):1137-1151.e15. doi: 10.1053/j.gastro.2023.02.030. Epub 2023 Mar 4. PubMed PMID: 36871599; PubMed Central PMCID: PMC10200762
He S, Lei P, Kang W, Cheung P, Xu T, Mana M, Park CY, Wang H, Imada S, Russell JO, Wang J, Wang R, Zhou Z, Chetal K, Stas E, Mohad V, Bruun-Rasmussen P, Sadreyev RI, Hodin RA, Zhang Y, Breault DT, Camargo FD, Yilmaz ÖH, Fredberg JJ, Saeidi N.
Live cell tagging tracking and isolation for spatial transcriptomics using photoactivable cell dyes
Nat Commun. (2021) Aug 17;12(1):4495. doi: 10.1038/s41467-021-25279-y. PubMed PMID: 34404785; PubMed Central PMCID: PMC8371137
Genshaft AS, Ziegler CGK, Tzouanas CN, Mead BE, Jaeger AM, Navia AW, King RP, Mana MD, Huang S, Mitsialis V, Snapper SB, Yilmaz ÖH, Jacks T, Van Humbeck JF, Shalek AK.
High-fat diet activates a PPAR-δ program to enhance intestinal stem cell function
Cell Stem Cell. (2021) April 1;28(4):598-599. doi: 10.1016/j.stem.2021.03.001. PubMed PMID:33798420; PubMed Central PMCID: PMC8875728
Beyaz S, Mana MD, Yilmaz ÖH.
High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
Cell Reports. (2021) Jun 8;Vol.35, Issue10. PMID:34107251
Mana MD *, Hussey AM, Tzouanas CN, Imada S, Barrera Millan Y, Bahceci D, Saiz DR, Webb AT, Lewis CA, Carmeliet P, Mihaylova MM, Shalek AK, and Yilmaz ÖH *.
* Co-corresponding
Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions
Clin Cancer Res. (2019). PMID: 31852835
Rickelt S, Condon C, Mana M, Whittaker C, Pfirschke C, Roper J, Patil DT, Brown I, Mattia AR, Zukerberg L, Zhao Q, Chetty R, Lauwers GY, Neyaz A, Leijssen LGJ, Boylan K, Yilmaz OH, Deshpande V, Hynes RO.
Gut organoids: mini-tissues in culture to study intestinal physiology and disease
Am J Physiol Cell Physiol. (2019) Sep 1;317(3):C405-C419. PMID:31216420
Almeqdadi M, Mana MD, Roper J,Yilmaz ÖH.
High-fat diet in a mouse insulin-resistant model induces widespread rewiring of the phosphotyrosine signaling network
Mol Syst Biol. 2019 Aug;15(8):e8849. PMID:31464373
Dittmann A, Kennedy NJ, Soltero NL, Morshed N, Mana MD, Yilmaz ÖH, Davis RJ, White FM.
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium
Nature. (2019) Jul;571(7765):398-402. PMID: 31292548
Pentinmikko N, Iqbal S, Mana M, Andersson S, Cognetta AB 3rd, Suciu RM, Roper J, Luopajärvi K, Markelin E, Gopalakrishnan S, Smolander OP, Naranjo S, Saarinen T, Juuti A, Pietiläinen K, Auvinen P, Ristimäki A, Gupta N, Tammela T, Jacks T, Sabatini DM, Cravatt BF, Yilmaz ÖH, Katajisto P.
Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging
Cell Stem Cell. (2018) 22, issue 5, 769-778. PMID:29727683
Maria M. Mihaylova *, Chia-Wei Cheng *, Amanda Q. Cao ^, Surya Tripathi ^, Miyeko D. Mana, Khristian E. Bauer-Rowe, Monther Abu-Remaileh, Laura Clavain, Aysegul Erdemir, Caroline A. Lewis, Elizaveta Freinkman, Audrey S. Dickey, Albert R. La Spada, Yanmei Huang, George W. Bell, Vikram Deshpande, Peter Carmeliet, Pekka Katajisto, David Sabatini, Omer Yilmaz.
* Equal Contribution, ^ Equal Contribution
Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells
Cell Stem Cell. 2017 June, v20; 6: 801-816. PMID: 28285904
Barriga M, Montagni E, Mana M, Mendez-Lago M, Hernando-Momblona X, Sevillano M, Guillaument-Adkins A, Rodriguez-Esteban G, Buczacki SJA, Gut M, Heyn H, Winton DJ, Yilmaz OH, Attolini CS-O, Gut I, Batlle E.
Dietary Regulation of Adult Stem Cells
Curr Stem Cell Rep. (2017) Mar 3(1):1-8. PMID:28966904
Mana MD *, Kuo EY *, Yilmaz ÖH.
* Equal Contribution
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation
Cell Stem Cell. 2016 Aug 4;19(2):205-216. PMID: 27184401
Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio IIC, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW.
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
Nature. (2016) Mar 3;531(7592): 53-58. PMID:26935695
Beyaz S *, Mana MD *, Roper J *, Kedrin D, Saadatpour A, Hong S-J, Bauer-Rowe KE, Xifaras ME, Akkad A, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Lamming D, Dogum R, Guo G, Selig M, Nielsen GP, Gupta N, Ferrone C, Deshpande V, Yuan G-C, Orkin SH, Sabatini DM, and Yilmaz ÖH.
* Equal Contribution